Depression, Symptoms & Treatment

Treating Depression:

Depression symptoms are most often treated with psychotherapy and antidepressant medications. It is believed that antidepressant medications work by increasing the levels of neurotransmitters in the brain. These changes have a positive effect on mood and on reducing feelings of depression and anxiety. Unfortunately, treating major depression is sometimes more complicated and requires more than antidepressant medication alone.

Although antidepressants can be effective for many patients, they do not work for everybody. Some patients may not respond to antidepressant medications. Additionally, since antidepressant medications are typically taken by mouth, they circulate in the bloodstream throughout the body, and may result in unwanted side effects such as weight gain, sexual problems, upset stomach, sleepiness, and dry mouth, among others. Over four million patients do not receive adequate benefit from antidepressant medications. When a patient does not respond or cannot tolerate antidepressants, this is sometimes referred to as treatment resistant depression. Treatment resistant depression is a debilitating condition for those dealing with it.

For these patients, alternative treatments for depression are available. These depression therapies have been shown to work in some people who do not receive benefit from antidepressant medications. Such patients may also be unable to tolerate the side effects caused by these medications.

These treatments may include: transcranial magnetic stimulation (TMS) , combination therapy (taking an antidepressant medication with an antipsychotic medication), electroconvulsive therapy (ECT) and vagus nerve stimulation (VNS).

Transcranial magnetic stimulation uses short pulses of magnetic fields to stimulate nerve cells in the area of the brain thought to control mood. These pulsed magnetic fields may have a positive effect on the brain’s neurotransmitters levels. Treating depression with transcranial magnetic stimulation, also referred to as TMS Therapy, may provide an alternative depression treatment for those who have not benefitted from prior antidepressant medication.*

About Depression:

Major depression is a serious medical illness affecting more than 14 million American adults every year.1 Often a debilitating disorder, depression results in a persistent state of sadness which interferes with an individual’s thoughts, behavior, mood, and physical health.

In 2000, the economic burden of depression was estimated at $83.1 billion in the US2 and researchers estimate that by the year 2020, depression will be the second leading cause of disability worldwide.3

Depression can be a lethal disease. In fact, each year in the US, over 30,000 people die by suicide, 60% of whom suffer from depression.4 Overall, women are almost twice as likely as men to suffer from depression; however, some experts feel that depression in men is under-reported.5 Depression has no racial, ethnic or socioeconomic boundaries. About two-thirds of those who experience an episode of depression will have at least one other episode in their lives.6

While the exact cause of depression is not known, the leading scientific theory is that depression is caused by an imbalance of the brain’s neurotransmitters. Neurotransmitters are chemical messengers that send signals between brain cells. Depression is most often treated with antidepressant medications. It is believed that antidepressant medications work by increasing the levels of these neurotransmitters.

More than 4 million patients do not receive adequate benefit from antidepressants1 which may in part be due to intolerance to their side effects. For these patients, they need a new way back.


1. Kessler, RC, et al. Prevalence, severity, and comorbidity of twelve-month DSM-IV disorders in the National Comorbidity Survey Replication (NCS-R). Archives of General Psychiatry, 2005 Jun: 62 (6):617-27.
2. Greenberg, PE, et al. The economic burden of depressive disorders in the United States: How did it change between 1990 and 2000? Journal of Clinical Psychiatry. 2003; 64 (12): 1465-1475.
3. Murray CJ, Lopez AD. Evidence-based health policy – lessons from the Global Burden of Disease Study. Science. 1996; 274 (5288): 740-743.
4. Heron, Melonie, et al. Deaths: Final Data for 2006. National Vital Statistics Reports, 57 (14). April 17, 2009.
5. Kessler, RC, et al. The epidemiology of major depressive disorder; results from the National Comorbidity Survey Replication (NCS-R). JAMA. 2003; 289(23): 3095-3105.
6. Data on file

Depression Symptoms:

Depression results in a persistent state of sadness or a loss of the ability to experience pleasure. Those experiencing depression often lose interest in everyday activities or hobbies that were once enjoyed.

According to the standard diagnosis guide (DSM-IV-TR) published by the American Psychiatric Association, depression is diagnosed when an individual is experiencing either a depressed mood or a loss of interest or pleasure plus four or more of the following symptoms during the same two-week period:

  • Significant weight loss (when not dieting) or weight gain (a change of more than five percent of body weight in a month)
  • Significant increase or decrease in appetite
  • Excessive sleepiness or insomnia
  • Agitation and restlessness
  • Fatigue or loss of energy nearly every day
  • Feelings of worthlessness or excessive and inappropriate guilt nearly every day
  • Diminished ability to think, concentrate, or make decisions
  • Recurrent thoughts of death or suicide
  • Significant weight gain or weight loss

If you feel you are experiencing any of these depression symptoms, contact your doctor and speak with them about your depression treatment options.

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